Human endothelial dysfunction: EDRFs
نویسندگان
چکیده
منابع مشابه
Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction
BACKGROUND Endothelial dysfunction contributes significantly to the development of vascular diseases. However, a therapy able to reduce this derangement still needs to be identified. We evaluated the effects of pharmacological inhibition of Rac1, a small GTPase protein promoting oxidative stress, in human endothelial dysfunction. METHODS AND RESULTS We performed vascular reactivity studies to...
متن کاملEndothelial Dysfunction
The study by Akiyama et al. (3), in this issue of the Journal, highlights a potential novel target in HFPEF. In this observational hospital-based study of 321 patients with HFPEF and 173 age-, sex-, and comorbidity-matched controls, endothelial function was assessed using reactive hyperemia peripheral arterial tonometry. Endothelial dysfunction (defined by a reactive hyperemia index below the m...
متن کاملEndothelial dysfunction.
Endothelial dysfunction is characterized by a shift of the actions of the endothelium toward reduced vasodilation, a proinflammatory state, and prothrombic properties. It is associated with most forms of cardiovascular disease, such as hypertension, coronary artery disease, chronic heart failure, peripheral artery disease, diabetes, and chronic renal failure. Mechanisms that participate in the ...
متن کاملFreeze fracture study of human corneal endothelial dysfunction.
Intramembrane changes occurring in dysfunctional corneal endothelial cell membranes were examined using freeze-fracture and transmission electron microscopy techniques. Three categories of dysfunctional endothelium were examined: aphakic bullous keratopathy, pseudophakic bullous keratopathy and Fuchs' endothelial dystrophy. Keratoconus corneas and a donor eye bank eye were examined as normal co...
متن کاملEndothelium-dependent contractions and endothelial dysfunction in human hypertension.
The endothelium is a crucial regulator of vascular physiology, producing in healthy conditions several substances with a potent antiatherosclerotic properties. Accordingly, the presence of endothelial dysfunction is associated with subclinical atherosclerosis and with an increased future risk of cardiovascular events. A large body of evidence supports the fundamental role of nitric oxide (NO) a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pflügers Archiv - European Journal of Physiology
سال: 2010
ISSN: 0031-6768,1432-2013
DOI: 10.1007/s00424-010-0822-4